Symbol: Name: ID: |
LAT linker for activation of T cells GFS:7695 |
Gene name: | LAT |
Chromosome: | 16q13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | LAT1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1342293 | Rat Genome Database ID: | RGD:620802 |
HGNC ID: | HGNC:18874 | RefSeq IDs: | NM_001014987 |
Entrez Gene ID: | 27040 | Ensembl Gene ID: | ENSG00000213658 |
VEGA IDs: | OTTHUMG00000131761 | UniProt ID: | O43561 |
UCSC ID: | OMIM ID: | 602354 | |
Pubmed: | PMID9489702 | ||
CCDS IDs: | CCDSCCDS10647.1 CCDS CCDS32425.1 CCDS CCDS45455.1 |
Linker of Activated T cells, also known as LAT, is a protein which in humans is encoded by the LAT gene.
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq)
Function: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Products for LAT gene
Catalog | Product Name | Application | Company |
GFS:E07695 | linker for activation of T cells; ELISA kit | ELISA | n/a |
GFS:A07695 | linker for activation of T cells; Anti | ANTIBODIES | n/a |
GFS:P07695 | linker for activation of T cells; Protien | Protien | n/a |