Symbol: Name: ID: |
KREMEN2 kringle containing transmembrane protein 2 GFS:7620 |
Gene name: | KREMEN2 |
Chromosome: | 16p13.11 |
Previous Symbols: | |
Previous Names: | |
Aliases: | MGC10791, KRM2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1920266 | Rat Genome Database ID: | RGD:1310795 |
HGNC ID: | HGNC:18797 | RefSeq IDs: | NM_024507 |
Entrez Gene ID: | 79412 | Ensembl Gene ID: | ENSG00000131650 |
VEGA IDs: | OTTHUMG00000128976 | UniProt ID: | Q8NCW0 |
UCSC ID: | uc002csg.2 | OMIM ID: | 609899 |
Pubmed: | PMID12050670 | ||
CCDS IDs: | CCDSCCDS10483.1 CCDS CCDS10484.1 |
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008].
Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane (By similarity).
Products for KREMEN2 gene
Catalog | Product Name | Application | Company |
GFS:E07620 | kringle containing transmembrane protein 2; ELISA kit | ELISA | n/a |
GFS:A07620 | kringle containing transmembrane protein 2; Anti | ANTIBODIES | n/a |
GFS:P07620 | kringle containing transmembrane protein 2; Protien | Protien | n/a |