Symbol: Name: ID: |
IL28A interleukin 28A (interferon, lambda 2) GFS:7231 |
Gene name: | IL28A |
Chromosome: | 19q13.13 |
Previous Symbols: | |
Previous Names: | interleukin 28A |
Aliases: | IL-28A, IFNL2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:3647279 | Rat Genome Database ID: | |
HGNC ID: | HGNC:18364 | RefSeq IDs: | NM_172138 |
Entrez Gene ID: | 282616 | Ensembl Gene ID: | ENSG00000183709 |
VEGA IDs: | UniProt ID: | Q8IZJ0 | |
UCSC ID: | uc002oku.1 | OMIM ID: | 607401 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS42567.1 |
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008].
Function: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.
Products for IL28A gene
Catalog | Product Name | Application | Company |
GFS:E07231 | interleukin 28A (interferon, lambda 2); ELISA kit | ELISA | n/a |
GFS:A07231 | interleukin 28A (interferon, lambda 2); Anti | ANTIBODIES | n/a |
GFS:P07231 | interleukin 28A (interferon, lambda 2); Protien | Protien | n/a |