Interleukin-1 family member 7 is a protein that in humans is encoded by the IL1F7 gene.

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Function: Binds to interleukin-18 receptor (IL-18R) receptor but not to IL-1 receptor. Could be a new player in the inflammatory and immune responses mediated by the IL-18/IL-18R axis.