Symbol: Name: ID: |
IL28RA interleukin 28 receptor, alpha (interferon, lambda receptor) GFS:7428 |
Gene name: | IL28RA |
Chromosome: | 1p36.11 |
Previous Symbols: | |
Previous Names: | interleukin 28 receptor, alpha |
Aliases: | CRF2/12, IFNLR, IL-28R1 |
Name Aliases: | interferon lambda receptor 1 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2429859 | Rat Genome Database ID: | RGD:1562689 |
HGNC ID: | HGNC:18584 | RefSeq IDs: | NM_170743 |
Entrez Gene ID: | 163702 | Ensembl Gene ID: | ENSG00000185436 |
VEGA IDs: | OTTHUMG00000003036 | UniProt ID: | Q8IU57 |
UCSC ID: | uc001bis.2 | OMIM ID: | 607404 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS248.1 CCDS CCDS249.1 CCDS CCDS250.1 |
Interleukin 28 receptor, alpha subunit is a subunit for the interleukin-28 receptor. IL28RA is its human gene.
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Function: The IL28RA/IL10RB dimer is a receptor for IL28A, IL28B and IL29. The ligand/receptor complex seems to signal through the Jak-STAT pathway.
Products for IL28RA gene
Catalog | Product Name | Application | Company |
GFS:E07428 | interleukin 28 receptor, alpha (interferon, lambda receptor); ELISA kit | ELISA | n/a |
GFS:A07428 | interleukin 28 receptor, alpha (interferon, lambda receptor); Anti | ANTIBODIES | n/a |
GFS:P07428 | interleukin 28 receptor, alpha (interferon, lambda receptor); Protien | Protien | n/a |