Symbol: Name: ID: |
IL27RA interleukin 27 receptor, alpha GFS:6374 |
Gene name: | IL27RA |
Chromosome: | 19p13.11 |
Previous Symbols: | |
Previous Names: | |
Aliases: | WSX-1, TCCR, CRL1, WSX1, zcytor1, IL-27R |
Name Aliases: | T-cell cytokine receptor type 1 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1355318 | Rat Genome Database ID: | RGD:1305029 |
HGNC ID: | HGNC:17290 | RefSeq IDs: | NM_004843 |
Entrez Gene ID: | 9466 | Ensembl Gene ID: | ENSG00000104998 |
VEGA IDs: | UniProt ID: | Q6UWB1 | |
UCSC ID: | uc002mxx.2 | OMIM ID: | 605350 |
Pubmed: | PMID9600072 PMID 11057672 | ||
CCDS IDs: | CCDSCCDS12303.1 |
Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene.
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
Products for IL27RA gene
Catalog | Product Name | Application | Company |
GFS:E06374 | interleukin 27 receptor, alpha; ELISA kit | ELISA | n/a |
GFS:A06374 | interleukin 27 receptor, alpha; Anti | ANTIBODIES | n/a |
GFS:P06374 | interleukin 27 receptor, alpha; Protien | Protien | n/a |