Symbol: Name: ID: |
IRAK4 interleukin-1 receptor-associated kinase 4 GFS:6863 |
Gene name: | IRAK4 |
Chromosome: | 12q12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | NY-REN-64 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2182474 | Rat Genome Database ID: | RGD:1305303 |
HGNC ID: | HGNC:17967 | RefSeq IDs: | NM_001114182 |
Entrez Gene ID: | 51135 | Ensembl Gene ID: | |
VEGA IDs: | UniProt ID: | Q9NWZ3 | |
UCSC ID: | uc001rnt.3 | OMIM ID: | 606883 |
Pubmed: | PMID3772297 PMID 10508479 | ||
CCDS IDs: | CCDSCCDS8744.1 CCDS CCDS44862.1 |
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Function: Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Phosphorylates IRAK1.
Products for IRAK4 gene
Catalog | Product Name | Application | Company |
GFS:E06863 | interleukin-1 receptor-associated kinase 4; ELISA kit | ELISA | n/a |
GFS:A06863 | interleukin-1 receptor-associated kinase 4; Anti | ANTIBODIES | n/a |
GFS:P06863 | interleukin-1 receptor-associated kinase 4; Protien | Protien | n/a |