Symbol: Name: ID: |
IRAK3 interleukin-1 receptor-associated kinase 3 GFS:6112 |
Gene name: | IRAK3 |
Chromosome: | 12q13.13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | IRAK-M |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1921164 | Rat Genome Database ID: | RGD:1308846 |
HGNC ID: | HGNC:17020 | RefSeq IDs: | NM_001142523 |
Entrez Gene ID: | 11213 | Ensembl Gene ID: | ENSG00000090376 |
VEGA IDs: | UniProt ID: | Q9Y616 | |
UCSC ID: | uc001sth.2 | OMIM ID: | 604459 |
Pubmed: | PMID10383454 | ||
CCDS IDs: | CCDSCCDS8975.1 CCDS CCDS44937.1 |
Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3 gene.
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
Function: Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity).
Products for IRAK3 gene
Catalog | Product Name | Application | Company |
GFS:E06112 | interleukin-1 receptor-associated kinase 3; ELISA kit | ELISA | n/a |
GFS:A06112 | interleukin-1 receptor-associated kinase 3; Anti | ANTIBODIES | n/a |
GFS:P06112 | interleukin-1 receptor-associated kinase 3; Protien | Protien | n/a |