Symbol: Name: ID: |
ING3 inhibitor of growth family, member 3 GFS:3893 |
Gene name: | ING3 |
Chromosome: | 7q31 |
Previous Symbols: | |
Previous Names: | |
Aliases: | p47ING3, FLJ20089, Eaf4, MEAF4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1919027 | Rat Genome Database ID: | RGD:1310556 |
HGNC ID: | HGNC:14587 | RefSeq IDs: | NM_019071 |
Entrez Gene ID: | 54556 | Ensembl Gene ID: | ENSG00000071243 |
VEGA IDs: | OTTHUMG00000141270 | UniProt ID: | Q9NXR8 |
UCSC ID: | uc003vjn.2 | OMIM ID: | 607493 |
Pubmed: | PMID12080476 | ||
CCDS IDs: | CCDSCCDS5778.1 CCDS CCDS35497.1 |
Inhibitor of growth protein 3 is a protein that in humans is encoded by the ING3 gene.
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008].
Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.
Products for ING3 gene
Catalog | Product Name | Application | Company |
GFS:E03893 | inhibitor of growth family, member 3; ELISA kit | ELISA | n/a |
GFS:A03893 | inhibitor of growth family, member 3; Anti | ANTIBODIES | n/a |
GFS:P03893 | inhibitor of growth family, member 3; Protien | Protien | n/a |