Symbol: Name: ID: |
HIF3A hypoxia inducible factor 3, alpha subunit GFS:4966 |
Gene name: | HIF3A |
Chromosome: | 19q13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | IPAS, MOP7, PASD7, bHLHe17 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1859778 | Rat Genome Database ID: | RGD:70332 |
HGNC ID: | HGNC:15825 | RefSeq IDs: | NM_022462 |
Entrez Gene ID: | 64344 | Ensembl Gene ID: | ENSG00000124440 |
VEGA IDs: | OTTHUMG00000141296 | UniProt ID: | Q9Y2N7 |
UCSC ID: | uc002peh.2 | OMIM ID: | 609976 |
Pubmed: | PMID11573933 PMID 11734856 | ||
CCDS IDs: | CCDSCCDS12681.2 CCDS CCDS12682.1 CCDS CCDS42580.1 |
Hypoxia-inducible factor 3 alpha is a protein that in humans is encoded by the HIF3A gene.
The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011].
Function: Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the cornea (By similarity).
Products for HIF3A gene
Catalog | Product Name | Application | Company |
GFS:E04966 | hypoxia inducible factor 3, alpha subunit; ELISA kit | ELISA | n/a |
GFS:A04966 | hypoxia inducible factor 3, alpha subunit; Anti | ANTIBODIES | n/a |
GFS:P04966 | hypoxia inducible factor 3, alpha subunit; Protien | Protien | n/a |