Symbol: Name: ID: |
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 GFS:7490 |
Gene name: | HSD17B12 |
Chromosome: | 11q11 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KAR, SDR12C1 |
Name Aliases: | 3-ketoacyl-CoA reductase, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1926967 | Rat Genome Database ID: | RGD:708367 |
HGNC ID: | HGNC:18646 | RefSeq IDs: | NM_016142 |
Entrez Gene ID: | 51144 | Ensembl Gene ID: | ENSG00000149084 |
VEGA IDs: | UniProt ID: | Q53GQ0 | |
UCSC ID: | uc001mxq.3 | OMIM ID: | 609574 |
Pubmed: | PMID12482854 PMID 19027726 | ||
CCDS IDs: | CCDSCCDS7905.1 |
Estradiol 17-beta-dehydrogenase 12 is an enzyme that in humans is encoded by the HSD17B12 gene.
This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011].
Function: Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.
Products for HSD17B12 gene
Catalog | Product Name | Application | Company |
GFS:E07490 | hydroxysteroid (17-beta) dehydrogenase 12; ELISA kit | ELISA | n/a |
GFS:A07490 | hydroxysteroid (17-beta) dehydrogenase 12; Anti | ANTIBODIES | n/a |
GFS:P07490 | hydroxysteroid (17-beta) dehydrogenase 12; Protien | Protien | n/a |