Symbol: Name: ID: |
HIST1H2BK histone cluster 1, H2bk GFS:3394 |
Gene name: | HIST1H2BK |
Chromosome: | 6p22.1 |
Previous Symbols: | H2BFT |
Previous Names: | H2B histone family, member T, "histone 1, H2bk" |
Aliases: | H2BFAiii |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2448399 | Rat Genome Database ID: | RGD:1308088 |
HGNC ID: | HGNC:13954 | RefSeq IDs: | NM_080593 |
Entrez Gene ID: | 85236 | Ensembl Gene ID: | ENSG00000197903 |
VEGA IDs: | OTTHUMG00000014473 | UniProt ID: | O60814 |
UCSC ID: | uc003nix.1 | OMIM ID: | |
Pubmed: | PMID12408966 | ||
CCDS IDs: | CCDSCCDS4621.1 |
Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Products for HIST1H2BK gene
Catalog | Product Name | Application | Company |
GFS:E03394 | histone cluster 1, H2bk; ELISA kit | ELISA | n/a |
GFS:A03394 | histone cluster 1, H2bk; Anti | ANTIBODIES | n/a |
GFS:P03394 | histone cluster 1, H2bk; Protien | Protien | n/a |