Symbol: Name: ID: |
HIST1H2AA histone cluster 1, H2aa GFS:7564 |
Gene name: | HIST1H2AA |
Chromosome: | 6p22.2 |
Previous Symbols: | |
Previous Names: | H2A histone family, member R, "histone 1, H2aa" |
Aliases: | bA317E16.2, H2AFR |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2448285 | Rat Genome Database ID: | RGD:3854 |
HGNC ID: | HGNC:18729 | RefSeq IDs: | NM_170745 |
Entrez Gene ID: | 221613 | Ensembl Gene ID: | ENSG00000164508 |
VEGA IDs: | OTTHUMG00000014407 | UniProt ID: | Q96QV6 |
UCSC ID: | uc003nfc.2 | OMIM ID: | 613499 |
Pubmed: | PMID12408966 | ||
CCDS IDs: | CCDSCCDS4562.1 |
Histone H2A type 1-A is a protein that in humans is encoded by the HIST1H2AA gene.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Products for HIST1H2AA gene
Catalog | Product Name | Application | Company |
GFS:E07564 | histone cluster 1, H2aa; ELISA kit | ELISA | n/a |
GFS:A07564 | histone cluster 1, H2aa; Anti | ANTIBODIES | n/a |
GFS:P07564 | histone cluster 1, H2aa; Protien | Protien | n/a |