Symbol: Name: ID: |
HES6 hairy and enhancer of split 6 (Drosophila) GFS:7126 |
Gene name: | HES6 |
Chromosome: | 2q37.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | bHLHb41 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1859852 | Rat Genome Database ID: | RGD:1312047 |
HGNC ID: | HGNC:18254 | RefSeq IDs: | NM_001142853 |
Entrez Gene ID: | 55502 | Ensembl Gene ID: | ENSG00000144485 |
VEGA IDs: | OTTHUMG00000133340 | UniProt ID: | Q96HZ4 |
UCSC ID: | uc002vxz.2 | OMIM ID: | 610331 |
Pubmed: | PMID10851137 | ||
CCDS IDs: | CCDSCCDS2527.1 CCDS CCDS46556.1 |
Transcription cofactor HES-6 is a protein that in humans is encoded by the HES6 gene.
This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008].
Function: Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentation (By similarity).
Products for HES6 gene
Catalog | Product Name | Application | Company |
GFS:E07126 | hairy and enhancer of split 6 (Drosophila); ELISA kit | ELISA | n/a |
GFS:A07126 | hairy and enhancer of split 6 (Drosophila); Anti | ANTIBODIES | n/a |
GFS:P07126 | hairy and enhancer of split 6 (Drosophila); Protien | Protien | n/a |