| Symbol: Name: ID: |
EGLN3 egl nine homolog 3 (C. elegans) GFS:3947 |
| Gene name: | EGLN3 |
| Chromosome: | 14q12 |
| Previous Symbols: | |
| Previous Names: | EGL nine (C.elegans) homolog 3 |
| Aliases: | PHD3, HIFPH3 |
| Name Aliases: | HIF prolyl hydroxylase 3 |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1932288 | Rat Genome Database ID: | RGD:71019 |
| HGNC ID: | HGNC:14661 | RefSeq IDs: | NM_022073 |
| Entrez Gene ID: | 112399 | Ensembl Gene ID: | ENSG00000129521 |
| VEGA IDs: | OTTHUMG00000029498 | UniProt ID: | Q9H6Z9 |
| UCSC ID: | uc001wsa.3 | OMIM ID: | 606426 |
| Pubmed: | |||
| CCDS IDs: | CCDSCCDS9646.1 | ||
Egl nine homolog 3 is a protein that in humans is encoded by the EGLN3 gene.
Function: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism (By similarity).
Products for EGLN3 gene
| Catalog | Product Name | Application | Company |
| GFS:E03947 | egl nine homolog 3 (C. elegans); ELISA kit | ELISA | n/a |
| GFS:A03947 | egl nine homolog 3 (C. elegans); Anti | ANTIBODIES | n/a |
| GFS:P03947 | egl nine homolog 3 (C. elegans); Protien | Protien | n/a |
