Symbol: Name: ID: |
EGLN1 egl nine homolog 1 (C. elegans) GFS:2135 |
Gene name: | EGLN1 |
Chromosome: | 1q42.1 |
Previous Symbols: | C1orf12 |
Previous Names: | EGL nine (C.elegans) homolog 1 |
Aliases: | SM-20, PHD2, ZMYND6, HIFPH2 |
Name Aliases: | HIF prolyl hydroxylase 2 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1932286 | Rat Genome Database ID: | RGD:631375 |
HGNC ID: | HGNC:1232 | RefSeq IDs: | NM_022051 |
Entrez Gene ID: | 54583 | Ensembl Gene ID: | ENSG00000135766 |
VEGA IDs: | OTTHUMG00000038027 | UniProt ID: | Q9GZT9 |
UCSC ID: | uc001huv.2 | OMIM ID: | 606425 |
Pubmed: | PMID11056053 | ||
CCDS IDs: | CCDSCCDS1595.1 |
Egl nine homolog 1 also known as prolyl hydroxylase domain-containing protein 2 (PHD2) or hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) is an enzyme that in humans is encoded by the EGLN1 gene. The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Products for EGLN1 gene
Catalog | Product Name | Application | Company |
GFS:E02135 | egl nine homolog 1 (C. elegans); ELISA kit | ELISA | n/a |
GFS:A02135 | egl nine homolog 1 (C. elegans); Anti | ANTIBODIES | n/a |
GFS:P02135 | egl nine homolog 1 (C. elegans); Protien | Protien | n/a |