Symbol: Name: ID: |
DYNLT1 dynein, light chain, Tctex-type 1 GFS:1514 |
Gene name: | DYNLT1 |
Chromosome: | 6q25.2-q25.3 |
Previous Symbols: | TCTEL1 |
Previous Names: | t-complex-associated-testis-expressed 1-like 1 |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98643 | Rat Genome Database ID: | RGD:620261 |
HGNC ID: | HGNC:11697 | RefSeq IDs: | NM_006519 |
Entrez Gene ID: | 6993 | Ensembl Gene ID: | ENSG00000146425 |
VEGA IDs: | OTTHUMG00000015918 | UniProt ID: | P63172 |
UCSC ID: | uc003qrn.1 | OMIM ID: | 601554 |
Pubmed: | PMID8646886 PMID 16260502 | ||
CCDS IDs: | CCDSCCDS5257.1 |
Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene. Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005 [PubMed 15992542]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein Function: Plays a role in neuronal morhpogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity).
Products for DYNLT1 gene
Catalog | Product Name | Application | Company |
GFS:E01514 | dynein, light chain, Tctex-type 1; ELISA kit | ELISA | n/a |
GFS:A01514 | dynein, light chain, Tctex-type 1; Anti | ANTIBODIES | n/a |
GFS:P01514 | dynein, light chain, Tctex-type 1; Protien | Protien | n/a |