Symbol: Name: ID: |
CYSLTR2 cysteinyl leukotriene receptor 2 GFS:7146 |
Gene name: | CYSLTR2 |
Chromosome: | 13q14.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CysLT(2), CYSLT2R |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1917336 | Rat Genome Database ID: | RGD:619797 |
HGNC ID: | HGNC:18274 | RefSeq IDs: | NM_020377 |
Entrez Gene ID: | 57105 | Ensembl Gene ID: | ENSG00000152207 |
VEGA IDs: | OTTHUMG00000016906 | UniProt ID: | Q9NS75 |
UCSC ID: | uc001vck.2 | OMIM ID: | 605666 |
Pubmed: | PMID10913337 PMID 1085123 | ||
CCDS IDs: | CCDSCCDS9412.1 |
Cysteinyl leukotriene receptor 2 is a protein that in humans is encoded by the CYSLTR2 gene.
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
Products for CYSLTR2 gene
Catalog | Product Name | Application | Company |
GFS:E07146 | cysteinyl leukotriene receptor 2; ELISA kit | ELISA | n/a |
GFS:A07146 | cysteinyl leukotriene receptor 2; Anti | ANTIBODIES | n/a |
GFS:P07146 | cysteinyl leukotriene receptor 2; Protien | Protien | n/a |