Symbol: Name: ID: |
CYSLTR1 cysteinyl leukotriene receptor 1 GFS:6502 |
Gene name: | CYSLTR1 |
Chromosome: | Xq13-q21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CysLT1, CysLT(1), CYSLT1R |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1926218 | Rat Genome Database ID: | RGD:619796 |
HGNC ID: | HGNC:17451 | RefSeq IDs: | NM_006639 |
Entrez Gene ID: | 10800 | Ensembl Gene ID: | ENSG00000173198 |
VEGA IDs: | OTTHUMG00000021889 | UniProt ID: | Q9Y271 |
UCSC ID: | uc004edb.2 | OMIM ID: | 300201 |
Pubmed: | PMID10391245 PMID 10462554 | ||
CCDS IDs: | CCDSCCDS14439.1 |
Cysteinyl leukotriene receptor 1 is a protein that in humans is encoded by the CYSLTR1 gene.
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
Products for CYSLTR1 gene
Catalog | Product Name | Application | Company |
GFS:E06502 | cysteinyl leukotriene receptor 1; ELISA kit | ELISA | n/a |
GFS:A06502 | cysteinyl leukotriene receptor 1; Anti | ANTIBODIES | n/a |
GFS:P06502 | cysteinyl leukotriene receptor 1; Protien | Protien | n/a |