Symbol: Name: ID: |
CCND3 cyclin D3 GFS:4986 |
Gene name: | CCND3 |
Chromosome: | 6p21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88315 | Rat Genome Database ID: | RGD:2293 |
HGNC ID: | HGNC:1585 | RefSeq IDs: | NM_001136017 |
Entrez Gene ID: | 896 | Ensembl Gene ID: | ENSG00000112576 |
VEGA IDs: | OTTHUMG00000014690 | UniProt ID: | P30281 |
UCSC ID: | uc003orn.2 | OMIM ID: | 123834 |
Pubmed: | PMID1386335 | ||
CCDS IDs: | CCDSCCDS4863.1 CCDS CCDS47425.1 CCDS CCDS47426.1 CCDS CCDS47427.1 |
G1/S-specific cyclin-D3 is a protein that in humans is encoded by the CCND3 gene.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
Function: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Products for CCND3 gene
Catalog | Product Name | Application | Company |
GFS:E04986 | cyclin D3; ELISA kit | ELISA | n/a |
GFS:A04986 | cyclin D3; Anti | ANTIBODIES | n/a |
GFS:P04986 | cyclin D3; Protien | Protien | n/a |