Symbol: Name: ID: |
CCND2 cyclin D2 GFS:4970 |
Gene name: | CCND2 |
Chromosome: | 12p13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | G1/S-specific cyclin D2 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88314 | Rat Genome Database ID: | RGD:621083 |
HGNC ID: | HGNC:1583 | RefSeq IDs: | NM_001759 |
Entrez Gene ID: | 894 | Ensembl Gene ID: | ENSG00000118971 |
VEGA IDs: | UniProt ID: | P30279 | |
UCSC ID: | uc001qmo.2 | OMIM ID: | 123833 |
Pubmed: | PMID1386335 | ||
CCDS IDs: | CCDSCCDS8524.1 |
G1/S-specific cyclin-D2 is a protein that in humans is encoded by the CCND2 gene.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. [provided by RefSeq, Oct 2008]. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for CCND2 gene
Catalog | Product Name | Application | Company |
GFS:E04970 | cyclin D2; ELISA kit | ELISA | n/a |
GFS:A04970 | cyclin D2; Anti | ANTIBODIES | n/a |
GFS:P04970 | cyclin D2; Protien | Protien | n/a |