Symbol: Name: ID: |
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 GFS:4618 |
Gene name: | CBFA2T3 |
Chromosome: | 16q24 |
Previous Symbols: | |
Previous Names: | |
Aliases: | MTGR2, ZMYND4, MTG16 |
Name Aliases: | myeloid translocation gene 8 and 16b |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1338013 | Rat Genome Database ID: | RGD:1310547 |
HGNC ID: | HGNC:1537 | RefSeq IDs: | NM_005187 |
Entrez Gene ID: | 863 | Ensembl Gene ID: | ENSG00000129993 |
VEGA IDs: | OTTHUMG00000137864 | UniProt ID: | O75081 |
UCSC ID: | uc002fmm.1 | OMIM ID: | 603870 |
Pubmed: | PMID9790752 | ||
CCDS IDs: | CCDSCCDS10972.1 CCDS CCDS10973.1 |
Protein CBFA2T3 is a protein that in humans is encoded by the CBFA2T3 gene.
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010].
Function: Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation.
Function: Isoform 2 functions as an A-kinase-anchoring protein.
Products for CBFA2T3 gene
Catalog | Product Name | Application | Company |
GFS:E04618 | core-binding factor, runt domain, alpha subunit 2; translocated to, 3; ELISA kit | ELISA | n/a |
GFS:A04618 | core-binding factor, runt domain, alpha subunit 2; translocated to, 3; Anti | ANTIBODIES | n/a |
GFS:P04618 | core-binding factor, runt domain, alpha subunit 2; translocated to, 3; Protien | Protien | n/a |