Symbol: Name: ID: |
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 GFS:4608 |
Gene name: | CBFA2T2 |
Chromosome: | 20q11 |
Previous Symbols: | |
Previous Names: | |
Aliases: | MTGR1, ZMYND3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1333833 | Rat Genome Database ID: | RGD:1309088 |
HGNC ID: | HGNC:1536 | RefSeq IDs: | NM_001032999 |
Entrez Gene ID: | 9139 | Ensembl Gene ID: | ENSG00000078699 |
VEGA IDs: | OTTHUMG00000032261 | UniProt ID: | O43439 |
UCSC ID: | uc002wze.1 | OMIM ID: | 603672 |
Pubmed: | PMID9790752 | ||
CCDS IDs: | CCDSCCDS13221.1 CCDS CCDS46590.1 |
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008].
Function: May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region.
Products for CBFA2T2 gene
Catalog | Product Name | Application | Company |
GFS:E04608 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2; ELISA kit | ELISA | n/a |
GFS:A04608 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2; Anti | ANTIBODIES | n/a |
GFS:P04608 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2; Protien | Protien | n/a |