Symbol: Name: ID: |
COLEC12 collectin sub-family member 12 GFS:5146 |
Gene name: | COLEC12 |
Chromosome: | 18pter-p11.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SRCL, CL-P1, SCARA4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2152907 | Rat Genome Database ID: | RGD:735039 |
HGNC ID: | HGNC:16016 | RefSeq IDs: | NM_130386 |
Entrez Gene ID: | 81035 | Ensembl Gene ID: | ENSG00000158270 |
VEGA IDs: | UniProt ID: | Q5KU26 | |
UCSC ID: | uc002kkm.2 | OMIM ID: | 607621 |
Pubmed: | PMID11162630 | ||
CCDS IDs: | CCDSCCDS32782.1 |
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that can bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. In addition, these receptors can recognize oxidized phospholipids so they may also participate in removing oxidatively damaged or apoptotic cells. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease.
Products for COLEC12 gene
Catalog | Product Name | Application | Company |
GFS:E05146 | collectin sub-family member 12; ELISA kit | ELISA | n/a |
GFS:A05146 | collectin sub-family member 12; Anti | ANTIBODIES | n/a |
GFS:P05146 | collectin sub-family member 12; Protien | Protien | n/a |