Symbol: Name: ID: |
CCR5 chemokine (C-C motif) receptor 5 GFS:5185 |
Gene name: | CCR5 |
Chromosome: | 3p21 |
Previous Symbols: | CMKBR5 |
Previous Names: | |
Aliases: | CKR-5, CC-CKR-5, CKR5, CD195, IDDM22 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107182 | Rat Genome Database ID: | RGD:620596 |
HGNC ID: | HGNC:1606 | RefSeq IDs: | NM_000579 |
Entrez Gene ID: | 1234 | Ensembl Gene ID: | ENSG00000160791 |
VEGA IDs: | OTTHUMG00000133481 | UniProt ID: | P51681 |
UCSC ID: | uc003cpo.3 | OMIM ID: | 601373 |
Pubmed: | PMID8639485 | ||
CCDS IDs: | CCDSCCDS2739.1 |
C-C chemokine receptor type 5, also known as CCR5, is a protein that in humans is encoded by the CCR5 gene.
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
Products for CCR5 gene
Catalog | Product Name | Application | Company |
GFS:E05185 | chemokine (C-C motif) receptor 5; ELISA kit | ELISA | n/a |
GFS:A05185 | chemokine (C-C motif) receptor 5; Anti | ANTIBODIES | n/a |
GFS:P05185 | chemokine (C-C motif) receptor 5; Protien | Protien | n/a |