Symbol: Name: ID: |
CAT catalase GFS:4418 |
Gene name: | CAT |
Chromosome: | 11p13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88271 | Rat Genome Database ID: | RGD:2279 |
HGNC ID: | HGNC:1516 | RefSeq IDs: | NM_001752 |
Entrez Gene ID: | 847 | Ensembl Gene ID: | ENSG00000121691 |
VEGA IDs: | OTTHUMG00000044353 | UniProt ID: | P04040 |
UCSC ID: | uc001mvm.2 | OMIM ID: | 115500 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS7891.1 |
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
Products for CAT gene
Catalog | Product Name | Application | Company |
GFS:E04418 | catalase; ELISA kit | ELISA | n/a |
GFS:A04418 | catalase; Anti | ANTIBODIES | n/a |
GFS:P04418 | catalase; Protien | Protien | n/a |