Symbol: Name: ID: |
CATSPER1 cation channel, sperm associated 1 GFS:6208 |
Gene name: | CATSPER1 |
Chromosome: | 11q12.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CATSPER |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2179947 | Rat Genome Database ID: | RGD:1593515 |
HGNC ID: | HGNC:17116 | RefSeq IDs: | NM_053054 |
Entrez Gene ID: | 117144 | Ensembl Gene ID: | ENSG00000175294 |
VEGA IDs: | OTTHUMG00000166668 | UniProt ID: | Q8NEC5 |
UCSC ID: | uc001ogt.2 | OMIM ID: | 606389 |
Pubmed: | PMID11675491 PMID 11595941 PMID 16382101 | ||
CCDS IDs: | CCDSCCDS8127.1 |
CatSper1, is a protein which in humans is encoded by the CATSPER1 gene.
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
Products for CATSPER1 gene
Catalog | Product Name | Application | Company |
GFS:E06208 | cation channel, sperm associated 1; ELISA kit | ELISA | n/a |
GFS:A06208 | cation channel, sperm associated 1; Anti | ANTIBODIES | n/a |
GFS:P06208 | cation channel, sperm associated 1; Protien | Protien | n/a |