Symbol: Name: ID: |
CES2 carboxylesterase 2 GFS:7485 |
Gene name: | CES2 |
Chromosome: | 16q22.1 |
Previous Symbols: | |
Previous Names: | carboxylesterase 2 (intestine, liver) |
Aliases: | CE-2, iCE, CES2A1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:3648740 | Rat Genome Database ID: | RGD:1560889 |
HGNC ID: | HGNC:1864 | RefSeq IDs: | NM_003869 |
Entrez Gene ID: | 8824 | Ensembl Gene ID: | ENSG00000172831 |
VEGA IDs: | OTTHUMG00000137517 | UniProt ID: | O00748 |
UCSC ID: | uc002eqr.2 | OMIM ID: | 605278 |
Pubmed: | PMID9169443 PMID 9144407 PMID 20931200 | ||
CCDS IDs: | CCDSCCDS10825.1 CCDS CCDS45507.1 |
Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene.
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010].
Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methyumbelliferyl acetate, heroin and 6-monoacetylmorphine.
Products for CES2 gene
Catalog | Product Name | Application | Company |
GFS:E07485 | carboxylesterase 2; ELISA kit | ELISA | n/a |
GFS:A07485 | carboxylesterase 2; Anti | ANTIBODIES | n/a |
GFS:P07485 | carboxylesterase 2; Protien | Protien | n/a |