Symbol: Name: ID: |
CES1 carboxylesterase 1 GFS:7475 |
Gene name: | CES1 |
Chromosome: | 16q22.2 |
Previous Symbols: | |
Previous Names: | carboxylesterase 1 (monocyte/macrophage serine esterase 1) |
Aliases: | HMSE, CES2, HMSE1, SES1, CEH, CES1A1, CES1A2 |
Name Aliases: | human monocyte/macrophage serine esterase 1 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88378 | Rat Genome Database ID: | |
HGNC ID: | HGNC:1863 | RefSeq IDs: | NM_001025194 |
Entrez Gene ID: | 1066 | Ensembl Gene ID: | ENSG00000198848 |
VEGA IDs: | UniProt ID: | P23141 | |
UCSC ID: | uc002eil.2 | OMIM ID: | 114835 |
Pubmed: | PMID2070086 PMID 20931200 | ||
CCDS IDs: | CCDSCCDS32450.1 CCDS CCDS45488.1 CCDS CCDS45489.1 |
Liver carboxylesterase 1 also known as carboxylesterase 1 (CES1, hCE-1 or CES1A1) is an enzyme that in humans is encoded by the CES1 gene.
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.
Products for CES1 gene
Catalog | Product Name | Application | Company |
GFS:E07475 | carboxylesterase 1; ELISA kit | ELISA | n/a |
GFS:A07475 | carboxylesterase 1; Anti | ANTIBODIES | n/a |
GFS:P07475 | carboxylesterase 1; Protien | Protien | n/a |