Symbol: Name: ID: |
BRD7 bromodomain containing 7 GFS:3669 |
Gene name: | BRD7 |
Chromosome: | 16q12.1 |
Previous Symbols: | |
Previous Names: | bromodomain-containing 7 |
Aliases: | CELTIX1, BP75 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1349766 | Rat Genome Database ID: | RGD:1309891 |
HGNC ID: | HGNC:14310 | RefSeq IDs: | NM_001173984 |
Entrez Gene ID: | 29117 | Ensembl Gene ID: | ENSG00000166164 |
VEGA IDs: | OTTHUMG00000133170 | UniProt ID: | Q9NPI1 |
UCSC ID: | uc002egf.1 | OMIM ID: | |
Pubmed: | PMID10526152 PMID 18809673 | ||
CCDS IDs: | CCDSCCDS10742.1 |
Bromodomain-containing protein 7 is a protein that in humans is encoded by the BRD7 gene.
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010].
Function: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase
Products for BRD7 gene
Catalog | Product Name | Application | Company |
GFS:E03669 | bromodomain containing 7; ELISA kit | ELISA | n/a |
GFS:A03669 | bromodomain containing 7; Anti | ANTIBODIES | n/a |
GFS:P03669 | bromodomain containing 7; Protien | Protien | n/a |