Symbol: Name: ID: |
APOA5 apolipoprotein A-V GFS:6371 |
Gene name: | APOA5 |
Chromosome: | 11q23 |
Previous Symbols: | |
Previous Names: | |
Aliases: | RAP3, APOA-V |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1913363 | Rat Genome Database ID: | RGD:70903 |
HGNC ID: | HGNC:17288 | RefSeq IDs: | NM_001166598 |
Entrez Gene ID: | 116519 | Ensembl Gene ID: | ENSG00000110243 |
VEGA IDs: | OTTHUMG00000046116 | UniProt ID: | Q6Q788 |
UCSC ID: | uc001ppr.2 | OMIM ID: | 606368 |
Pubmed: | PMID11588264 PMID 11577099 | ||
CCDS IDs: | CCDSCCDS8376.2 |
Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene.
The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009].
Function: Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.
Products for APOA5 gene
Catalog | Product Name | Application | Company |
GFS:E06371 | apolipoprotein A-V; ELISA kit | ELISA | n/a |
GFS:A06371 | apolipoprotein A-V; Anti | ANTIBODIES | n/a |
GFS:P06371 | apolipoprotein A-V; Protien | Protien | n/a |