Symbol: Name: ID: |
ANAPC5 anaphase promoting complex subunit 5 GFS:4875 |
Gene name: | ANAPC5 |
Chromosome: | 12q24 |
Previous Symbols: | |
Previous Names: | |
Aliases: | APC5 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1929722 | Rat Genome Database ID: | RGD:1306125 |
HGNC ID: | HGNC:15713 | RefSeq IDs: | NM_001137559 |
Entrez Gene ID: | 51433 | Ensembl Gene ID: | ENSG00000089053 |
VEGA IDs: | UniProt ID: | Q9UJX4 | |
UCSC ID: | uc001uag.2 | OMIM ID: | 606948 |
Pubmed: | PMID9469815 | ||
CCDS IDs: | CCDSCCDS9220.1 CCDS CCDS45000.1 |
Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008].
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Products for ANAPC5 gene
Catalog | Product Name | Application | Company |
GFS:E04875 | anaphase promoting complex subunit 5; ELISA kit | ELISA | n/a |
GFS:A04875 | anaphase promoting complex subunit 5; Anti | ANTIBODIES | n/a |
GFS:P04875 | anaphase promoting complex subunit 5; Protien | Protien | n/a |