Symbol: Name: ID: |
WT1 Wilms tumor 1 GFS:2553 |
Gene name: | WT1 |
Chromosome: | 11p13 |
Previous Symbols: | GUD |
Previous Names: | |
Aliases: | WAGR, WIT-2, AWT1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98968 | Rat Genome Database ID: | RGD:3974 |
HGNC ID: | HGNC:12796 | RefSeq IDs: | NM_000378 |
Entrez Gene ID: | 7490 | Ensembl Gene ID: | |
VEGA IDs: | OTTHUMG00000039556 | UniProt ID: | P19544 |
UCSC ID: | uc001mtn.1 | OMIM ID: | 607102 |
Pubmed: | PMID14681303 | ||
CCDS IDs: | CCDSCCDS7878.2 CCDS CCDS44561.1 CCDS CCDS44562.1 |
Wilms tumor protein is a protein that in humans is encoded by the WT1 gene.
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Oct 2010].
Products for WT1 gene
Catalog | Product Name | Application | Company |
GFS:E02553 | Wilms tumor 1; ELISA kit | ELISA | n/a |
GFS:A02553 | Wilms tumor 1; Anti | ANTIBODIES | n/a |
GFS:P02553 | Wilms tumor 1; Protien | Protien | n/a |