Symbol: Name: ID: |
WTAP Wilms tumor 1 associated protein GFS:5932 |
Gene name: | WTAP |
Chromosome: | 6q25-q27 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0105, MGC3925 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1926395 | Rat Genome Database ID: | |
HGNC ID: | HGNC:16846 | RefSeq IDs: | NM_004906 |
Entrez Gene ID: | 9589 | Ensembl Gene ID: | ENSG00000146457 |
VEGA IDs: | OTTHUMG00000015933 | UniProt ID: | Q15007 |
UCSC ID: | uc003qsl.2 | OMIM ID: | 605442 |
Pubmed: | PMID7788527 PMID 11001926 | ||
CCDS IDs: | CCDSCCDS5266.1 CCDS CCDS5267.1 |
Pre-mRNA-splicing regulator WTAP is a protein that in humans is encoded by the WTAP gene.
The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform. [provided by RefSeq, Jul 2008].
Function: Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation.
Products for WTAP gene
Catalog | Product Name | Application | Company |
GFS:E05932 | Wilms tumor 1 associated protein; ELISA kit | ELISA | n/a |
GFS:A05932 | Wilms tumor 1 associated protein; Anti | ANTIBODIES | n/a |
GFS:P05932 | Wilms tumor 1 associated protein; Protien | Protien | n/a |