Symbol: Name: ID: |
WWP2 WW domain containing E3 ubiquitin protein ligase 2 GFS:5889 |
Gene name: | WWP2 |
Chromosome: | 16q22.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | AIP2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914144 | Rat Genome Database ID: | RGD:1310091 |
HGNC ID: | HGNC:16804 | RefSeq IDs: | NM_007014 |
Entrez Gene ID: | 11060 | Ensembl Gene ID: | ENSG00000198373 |
VEGA IDs: | OTTHUMG00000137573 | UniProt ID: | O00308 |
UCSC ID: | uc002exu.1 | OMIM ID: | 602308 |
Pubmed: | PMID9169421 PMID 12167593 | ||
CCDS IDs: | CCDSCCDS10885.1 |
NEDD4-like E3 ubiquitin-protein ligase WWP2 also known as atrophin-1-interacting protein 2 (AIP2) or WW domain-containing protein 2 (WWP2) is an enzyme that in humans is encoded by the WWP2 gene.
This gene encodes a member of the NEDD4-like protein family. The family of proteins is known to possess ubiquitin-protein ligase activity. The encoded protein contains 4 tandem WW domains. The WW domain is a protein motif consisting of 35 to 40 amino acids and is characterized by 4 conserved aromatic residues. The WW domain may mediate specific protein-protein interactions. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
Products for WWP2 gene
Catalog | Product Name | Application | Company |
GFS:E05889 | WW domain containing E3 ubiquitin protein ligase 2; ELISA kit | ELISA | n/a |
GFS:A05889 | WW domain containing E3 ubiquitin protein ligase 2; Anti | ANTIBODIES | n/a |
GFS:P05889 | WW domain containing E3 ubiquitin protein ligase 2; Protien | Protien | n/a |