Symbol: Name: ID: |
WWP1 WW domain containing E3 ubiquitin protein ligase 1 GFS:6096 |
Gene name: | WWP1 |
Chromosome: | 8q21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | AIP5, DKFZP434D2111 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1861728 | Rat Genome Database ID: | RGD:1311734 |
HGNC ID: | HGNC:17004 | RefSeq IDs: | NM_007013 |
Entrez Gene ID: | 11059 | Ensembl Gene ID: | ENSG00000123124 |
VEGA IDs: | UniProt ID: | Q9H0M0 | |
UCSC ID: | uc003ydt.2 | OMIM ID: | 602307 |
Pubmed: | PMID9169421 PMID 9647693 | ||
CCDS IDs: | CCDSCCDS6242.1 |
NEDD4-like E3 ubiquitin-protein ligase WWP1 is an enzyme that in humans is encoded by the WWP1 gene.
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7.
Products for WWP1 gene
Catalog | Product Name | Application | Company |
GFS:E06096 | WW domain containing E3 ubiquitin protein ligase 1; ELISA kit | ELISA | n/a |
GFS:A06096 | WW domain containing E3 ubiquitin protein ligase 1; Anti | ANTIBODIES | n/a |
GFS:P06096 | WW domain containing E3 ubiquitin protein ligase 1; Protien | Protien | n/a |