Symbol: Name: ID: |
WNK4 WNK lysine deficient protein kinase 4 GFS:3858 |
Gene name: | WNK4 |
Chromosome: | 17q21-q22 |
Previous Symbols: | PRKWNK4 |
Previous Names: | protein kinase, lysine deficient 4 |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1917097 | Rat Genome Database ID: | RGD:631401 |
HGNC ID: | HGNC:14544 | RefSeq IDs: | NM_032387 |
Entrez Gene ID: | 65266 | Ensembl Gene ID: | ENSG00000126562 |
VEGA IDs: | UniProt ID: | Q96J92 | |
UCSC ID: | uc002ibj.2 | OMIM ID: | 601844 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS11439.1 |
Serine/threonine-protein kinase WNK4 also known as WNK lysine deficient protein kinase 4 or WNK4, is an enzyme that in humans is encoded by the WNK4 gene.
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis (By similarity).
Products for WNK4 gene
Catalog | Product Name | Application | Company |
GFS:E03858 | WNK lysine deficient protein kinase 4; ELISA kit | ELISA | n/a |
GFS:A03858 | WNK lysine deficient protein kinase 4; Anti | ANTIBODIES | n/a |
GFS:P03858 | WNK lysine deficient protein kinase 4; Protien | Protien | n/a |