Symbol: Name: ID: |
WNK1 WNK lysine deficient protein kinase 1 GFS:3854 |
Gene name: | WNK1 |
Chromosome: | 12p13.3 |
Previous Symbols: | PRKWNK1, HSN2 |
Previous Names: | protein kinase, lysine deficient 1, "hereditary sensory neuropathy, type II" |
Aliases: | HSAN2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2442092 | Rat Genome Database ID: | RGD:621141 |
HGNC ID: | HGNC:14540 | RefSeq IDs: | NM_001184985 |
Entrez Gene ID: | 65125 | Ensembl Gene ID: | ENSG00000060237 |
VEGA IDs: | OTTHUMG00000090321 | UniProt ID: | Q9H4A3 |
UCSC ID: | uc001qio.3 | OMIM ID: | 605232 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS8506.1 |
WNK lysine deficient protein kinase 1, also known as WNK1, is an enzyme which in humans is encoded by the WNK1 gene.The human gene is located on short arm of chromosome 12 (12p13.3).
This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010].
Function: Controls sodium and chloride ion transport by inhibiting the activity of WNK4, potentially by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization.
Products for WNK1 gene
Catalog | Product Name | Application | Company |
GFS:E03854 | WNK lysine deficient protein kinase 1; ELISA kit | ELISA | n/a |
GFS:A03854 | WNK lysine deficient protein kinase 1; Anti | ANTIBODIES | n/a |
GFS:P03854 | WNK lysine deficient protein kinase 1; Protien | Protien | n/a |