Symbol: Name: ID: |
WDR5 WD repeat domain 5 GFS:2518 |
Gene name: | WDR5 |
Chromosome: | 9q34 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SWD3 |
Name Aliases: | SWD3, Set1c WD40 repeat protein, homolog (S. cerevisiae) |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2155884 | Rat Genome Database ID: | RGD:1305159 |
HGNC ID: | HGNC:12757 | RefSeq IDs: | NM_017588 |
Entrez Gene ID: | 11091 | Ensembl Gene ID: | ENSG00000196363 |
VEGA IDs: | OTTHUMG00000131707 | UniProt ID: | P61964 |
UCSC ID: | uc004cey.2 | OMIM ID: | 609012 |
Pubmed: | PMID11551928 | ||
CCDS IDs: | CCDSCCDS6981.1 |
WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq].
Function: Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May regulate osteoblasts differentiation.
Products for WDR5 gene
Catalog | Product Name | Application | Company |
GFS:E02518 | WD repeat domain 5; ELISA kit | ELISA | n/a |
GFS:A02518 | WD repeat domain 5; Anti | ANTIBODIES | n/a |
GFS:P02518 | WD repeat domain 5; Protien | Protien | n/a |