Symbol: Name: ID: |
WDR4 WD repeat domain 4 GFS:2517 |
Gene name: | WDR4 |
Chromosome: | 21q22.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TRM82 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1889002 | Rat Genome Database ID: | |
HGNC ID: | HGNC:12756 | RefSeq IDs: | NM_018669 |
Entrez Gene ID: | 10785 | Ensembl Gene ID: | ENSG00000160193 |
VEGA IDs: | OTTHUMG00000086826 | UniProt ID: | P57081 |
UCSC ID: | uc002zci.2 | OMIM ID: | 605924 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS13691.1 |
tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 is an enzyme that in humans is encoded by the WDR4 gene.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
Function: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational change of the catalytic subunit.
Products for WDR4 gene
Catalog | Product Name | Application | Company |
GFS:E02517 | WD repeat domain 4; ELISA kit | ELISA | n/a |
GFS:A02517 | WD repeat domain 4; Anti | ANTIBODIES | n/a |
GFS:P02517 | WD repeat domain 4; Protien | Protien | n/a |