Symbol: Name: ID: |
ULBP2 UL16 binding protein 2 GFS:4181 |
Gene name: | ULBP2 |
Chromosome: | 6q25 |
Previous Symbols: | |
Previous Names: | |
Aliases: | RAET1H |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:14894 | RefSeq IDs: | NM_025217 |
Entrez Gene ID: | 80328 | Ensembl Gene ID: | ENSG00000131015 |
VEGA IDs: | UniProt ID: | Q9BZM5 | |
UCSC ID: | uc003qno.2 | OMIM ID: | 605698 |
Pubmed: | PMID11239445 | ||
CCDS IDs: | CCDSCCDS5222.1 |
NKG2D ligand 2 is a protein that in humans is encoded by the ULBP2 gene
Function: Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
Products for ULBP2 gene
Catalog | Product Name | Application | Company |
GFS:E04181 | UL16 binding protein 2; ELISA kit | ELISA | n/a |
GFS:A04181 | UL16 binding protein 2; Anti | ANTIBODIES | n/a |
GFS:P04181 | UL16 binding protein 2; Protien | Protien | n/a |