Symbol: Name: ID: |
TIMP2 TIMP metallopeptidase inhibitor 2 GFS:1636 |
Gene name: | TIMP2 |
Chromosome: | 17q25 |
Previous Symbols: | |
Previous Names: | tissue inhibitor of metalloproteinase 2 |
Aliases: | CSC-21K |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98753 | Rat Genome Database ID: | RGD:61312 |
HGNC ID: | HGNC:11821 | RefSeq IDs: | NM_003255 |
Entrez Gene ID: | 7077 | Ensembl Gene ID: | ENSG00000035862 |
VEGA IDs: | OTTHUMG00000154517 | UniProt ID: | P16035 |
UCSC ID: | uc002jwf.2 | OMIM ID: | 188825 |
Pubmed: | PMID1427908 | ||
CCDS IDs: | CCDSCCDS11758.1 |
TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor. This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
Products for TIMP2 gene
Catalog | Product Name | Application | Company |
GFS:E01636 | TIMP metallopeptidase inhibitor 2; ELISA kit | ELISA | n/a |
GFS:A01636 | TIMP metallopeptidase inhibitor 2; Anti | ANTIBODIES | n/a |
GFS:P01636 | TIMP metallopeptidase inhibitor 2; Protien | Protien | n/a |