Symbol: Name: ID: |
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 GFS:1006 |
Gene name: | SMARCA2 |
Chromosome: | 9p24.3 |
Previous Symbols: | SNF2L2 |
Previous Names: | |
Aliases: | BAF190, hSNF2a, hBRM, Sth1p, SNF2LA, BRM, SNF2, SWI2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:99603 | Rat Genome Database ID: | RGD:1302988 |
HGNC ID: | HGNC:11098 | RefSeq IDs: | NM_003070 |
Entrez Gene ID: | 6595 | Ensembl Gene ID: | ENSG00000080503 |
VEGA IDs: | OTTHUMG00000019445 | UniProt ID: | P51531 |
UCSC ID: | uc003zhc.2 | OMIM ID: | 600014 |
Pubmed: | PMID8012116 | ||
CCDS IDs: | CCDSCCDS34977.1 CCDS CCDS34978.1 |
Probable global transcription activator SNF2L2 is a protein that in humans is encoded by the SMARCA2 gene. The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq].
Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)
Products for SMARCA2 gene
Catalog | Product Name | Application | Company |
GFS:E01006 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2; ELISA kit | ELISA | n/a |
GFS:A01006 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2; Anti | ANTIBODIES | n/a |
GFS:P01006 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2; Protien | Protien | n/a |