Symbol: Name: ID: |
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 GFS:6765 |
Gene name: | SENP3 |
Chromosome: | 17p13 |
Previous Symbols: | |
Previous Names: | SUMO1/sentrin/SMT3 specific protease 3 |
Aliases: | DKFZP586K0919, SSP3, DKFZp762A152, SMT3IP1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2158736 | Rat Genome Database ID: | RGD:1312040 |
HGNC ID: | HGNC:17862 | RefSeq IDs: | NM_015670 |
Entrez Gene ID: | 26168 | Ensembl Gene ID: | ENSG00000161956 |
VEGA IDs: | UniProt ID: | Q9H4L4 | |
UCSC ID: | uc002ghm.2 | OMIM ID: | 612844 |
Pubmed: | PMID10806345 PMID 11230166 | ||
CCDS IDs: |
SUMO1/sentrin/SMT3 specific peptidase 3, also known as SENP3, is a protein which in humans is encoded by the SENP3 gene.
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1.
Products for SENP3 gene
Catalog | Product Name | Application | Company |
GFS:E06765 | SUMO1/sentrin/SMT3 specific peptidase 3; ELISA kit | ELISA | n/a |
GFS:A06765 | SUMO1/sentrin/SMT3 specific peptidase 3; Anti | ANTIBODIES | n/a |
GFS:P06765 | SUMO1/sentrin/SMT3 specific peptidase 3; Protien | Protien | n/a |