Symbol: Name: ID: |
SH3KBP1 SH3-domain kinase binding protein 1 GFS:3330 |
Gene name: | SH3KBP1 |
Chromosome: | Xp22.1-p21.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CIN85 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1889583 | Rat Genome Database ID: | RGD:620904 |
HGNC ID: | HGNC:13867 | RefSeq IDs: | NM_001024666 |
Entrez Gene ID: | 30011 | Ensembl Gene ID: | ENSG00000147010 |
VEGA IDs: | OTTHUMG00000021227 | UniProt ID: | Q96B97 |
UCSC ID: | uc004czm.2 | OMIM ID: | 300374 |
Pubmed: | PMID8889549 PMID 7566098 | ||
CCDS IDs: | CCDSCCDS14193.1 CCDS CCDS35213.1 |
SH3 domain-containing kinase-binding protein 1 is an enzyme that in humans is encoded by the SH3KBP1 gene.
This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
Function: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis.
Products for SH3KBP1 gene
Catalog | Product Name | Application | Company |
GFS:E03330 | SH3-domain kinase binding protein 1; ELISA kit | ELISA | n/a |
GFS:A03330 | SH3-domain kinase binding protein 1; Anti | ANTIBODIES | n/a |
GFS:P03330 | SH3-domain kinase binding protein 1; Protien | Protien | n/a |