Symbol: Name: ID: |
SH3BP2 SH3-domain binding protein 2 GFS:740 |
Gene name: | SH3BP2 |
Chromosome: | 4p16.3 |
Previous Symbols: | |
Previous Names: | Cherubism |
Aliases: | RES4-23, CRBM |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1346349 | Rat Genome Database ID: | RGD:1310588 |
HGNC ID: | HGNC:10825 | RefSeq IDs: | NM_001122681 |
Entrez Gene ID: | 6452 | Ensembl Gene ID: | ENSG00000087266 |
VEGA IDs: | UniProt ID: | P78314 | |
UCSC ID: | uc003gfj.3 | OMIM ID: | 602104 |
Pubmed: | PMID9299232 PMID 11381256 | ||
CCDS IDs: | CCDSCCDS33944.1 |
The protein encoded by SH3BP2 has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
Products for SH3BP2 gene
Catalog | Product Name | Application | Company |
GFS:E00740 | SH3-domain binding protein 2; ELISA kit | ELISA | n/a |
GFS:A00740 | SH3-domain binding protein 2; Anti | ANTIBODIES | n/a |
GFS:P00740 | SH3-domain binding protein 2; Protien | Protien | n/a |