Symbol: Name: ID: |
SH3RF1 SH3 domain containing ring finger 1 GFS:6605 |
Gene name: | SH3RF1 |
Chromosome: | 4q32.3 |
Previous Symbols: | SH3MD2 |
Previous Names: | SH3 multiple domains 2 |
Aliases: | POSH, RNF142, KIAA1494 |
Name Aliases: | plenty of SH3 domains |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1913066 | Rat Genome Database ID: | RGD:735154 |
HGNC ID: | HGNC:17650 | RefSeq IDs: | NM_020870 |
Entrez Gene ID: | 57630 | Ensembl Gene ID: | ENSG00000154447 |
VEGA IDs: | UniProt ID: | Q7Z6J0 | |
UCSC ID: | uc003isa.1 | OMIM ID: | |
Pubmed: | PMID9482736 | ||
CCDS IDs: | CCDSCCDS34099.1 |
Putative E3 ubiquitin-protein ligase SH3RF1 is an enzyme that in humans is encoded by the SH3RF1 gene.
This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008].
Function: Acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9) (By similarity). May be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane.
Function: Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes such as UBE2D1 or UBE2N and then transfers it to substrates. In the absence of an external substrate, it can catalyze self-ubiquitination.
Products for SH3RF1 gene
Catalog | Product Name | Application | Company |
GFS:E06605 | SH3 domain containing ring finger 1; ELISA kit | ELISA | n/a |
GFS:A06605 | SH3 domain containing ring finger 1; Anti | ANTIBODIES | n/a |
GFS:P06605 | SH3 domain containing ring finger 1; Protien | Protien | n/a |