Symbol: Name: ID: |
SET SET nuclear oncogene GFS:679 |
Gene name: | SET |
Chromosome: | 9q34 |
Previous Symbols: | |
Previous Names: | SET translocation (myeloid leukemia-associated) |
Aliases: | PHAPII, 2PP2A, IPP2A2 |
Name Aliases: | protein phosphatase type 2A inhibitor, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1860267 | Rat Genome Database ID: | RGD:1307467 |
HGNC ID: | HGNC:10760 | RefSeq IDs: | NM_001122821 |
Entrez Gene ID: | 6418 | Ensembl Gene ID: | ENSG00000119335 |
VEGA IDs: | OTTHUMG00000020755 | UniProt ID: | Q01105 |
UCSC ID: | uc004bvu.3 | OMIM ID: | 600960 |
Pubmed: | PMID1630450 PMID 8626647 | ||
CCDS IDs: | CCDSCCDS6907.1 CCDS CCDS48037.1 |
Protein SET is a protein that in humans is encoded by the SET gene.Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher
Products for SET gene
Catalog | Product Name | Application | Company |
GFS:E00679 | SET nuclear oncogene; ELISA kit | ELISA | n/a |
GFS:A00679 | SET nuclear oncogene; Anti | ANTIBODIES | n/a |
GFS:P00679 | SET nuclear oncogene; Protien | Protien | n/a |