Symbol: Name: ID: |
SETDB1 SET domain, bifurcated 1 GFS:680 |
Gene name: | SETDB1 |
Chromosome: | 1q21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KG1T, KIAA0067, ESET, KMT1E |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1934229 | Rat Genome Database ID: | |
HGNC ID: | HGNC:10761 | RefSeq IDs: | NM_001145415 |
Entrez Gene ID: | 9869 | Ensembl Gene ID: | ENSG00000143379 |
VEGA IDs: | OTTHUMG00000035003 | UniProt ID: | Q15047 |
UCSC ID: | uc001evu.2 | OMIM ID: | 604396 |
Pubmed: | PMID10343109 | ||
CCDS IDs: | CCDSCCDS972.1 CCDS CCDS44217.1 |
Histone-lysine N-methyltransferase SETDB1 is an enzyme that in humans is encoded by the SETDB1 gene.This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins
Products for SETDB1 gene
Catalog | Product Name | Application | Company |
GFS:E00680 | SET domain, bifurcated 1; ELISA kit | ELISA | n/a |
GFS:A00680 | SET domain, bifurcated 1; Anti | ANTIBODIES | n/a |
GFS:P00680 | SET domain, bifurcated 1; Protien | Protien | n/a |