Symbol: Name: ID: |
SEC14L2 SEC14-like 2 (S. cerevisiae) GFS:617 |
Gene name: | SEC14L2 |
Chromosome: | 22q12.2 |
Previous Symbols: | C22orf6 |
Previous Names: | SEC14 (S. cerevisiae)-like 2 |
Aliases: | TAP, SPF, KIAA1186, KIAA1658 |
Name Aliases: | supernatant protein factor |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1915065 | Rat Genome Database ID: | RGD:621779 |
HGNC ID: | HGNC:10699 | RefSeq IDs: | NM_001204204 |
Entrez Gene ID: | 23541 | Ensembl Gene ID: | ENSG00000100003 |
VEGA IDs: | OTTHUMG00000151024 | UniProt ID: | O76054 |
UCSC ID: | uc003ahr.2 | OMIM ID: | 607558 |
Pubmed: | PMID10591208 | ||
CCDS IDs: | CCDSCCDS13876.1 CCDS CCDS46685.1 |
SEC14-like protein 2 is a protein that in humans is encoded by the SEC14L2 gene.This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq].
Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
Products for SEC14L2 gene
Catalog | Product Name | Application | Company |
GFS:E00617 | SEC14-like 2 (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A00617 | SEC14-like 2 (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P00617 | SEC14-like 2 (S. cerevisiae); Protien | Protien | n/a |